{"created":"2023-06-19T08:35:14.452406+00:00","id":1304,"links":{},"metadata":{"_buckets":{"deposit":"f1e08bf4-77a1-4edf-9373-79059e22c60b"},"_deposit":{"created_by":2,"id":"1304","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1304"},"status":"published"},"_oai":{"id":"oai:gunma-u.repo.nii.ac.jp:00001304","sets":["380:381"]},"author_link":["1710","1707","1703","1704","1706","1708","1705","1701","1709","1702"],"item_6_alternative_title_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"THE MECHANISM OF INCREASED THYROIDAL FUNCTION CAUSED BY (±)-4-DIETHYLAMINO-1,1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRIDTE(NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, ADMINISTRATION IN RATS"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-04-25","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"199","bibliographicPageStart":"187","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Journal of toxicological sciences"}]}]},"item_6_date_61":{"attribute_name":"更新日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-27","subitem_date_issued_type":"Created"}]},"item_6_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_39":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A study was conducted to elucidate the mechanism of the increased thyroidal function caused by oral administration of (±)-4-diethylamino-1,1-dimethylbut-2-yn- 1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a new drug for the treatment of urinary frequency and incontinence, in rats. Rats were given 500 mg/kg of NS-21 orally for 13 weeks. Rats were also given 500 mg/kg of the drug and 15 μg/animal of thyroxine (T_4) in order to assess the influence of T_4 treatment. NS-21 caused decreases in both total and free T_4 and increases in TSH and thyroxine uridine diphosphate glucuronyltransferase (T_4UDP-GT). Morphological examination of thyroid gland revealed stimulated follicles indicating heightened thyroidal function. The treatment of T_4 inhibited the stimulating effect of NS-21 on thyroid gland. These results show that the administration of NS-21 caused induction of T_4UDP-GT, which resulted in a compensatory stimulation of the thyroidal function by the increased secretion of pituitary TSH in response to increased blood thyroid hormone metabolism.","subitem_description_type":"Abstract"}]},"item_6_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本トキシコロジー学会"}]},"item_6_relation_43":{"attribute_name":"異版である","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110001803672/","subitem_relation_type_select":"URI"}}]},"item_6_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"},{"subitem_rights":"日本トキシコロジー学会"}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0388-1350","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00002808","subitem_source_identifier_type":"NCID"}]},"item_6_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石橋, 成太良"}],"nameIdentifiers":[{"nameIdentifier":"1701","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中沢, 素邦"}],"nameIdentifiers":[{"nameIdentifier":"1702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"俵谷, 武治"}],"nameIdentifiers":[{"nameIdentifier":"1703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 勝"}],"nameIdentifiers":[{"nameIdentifier":"1704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田村, 博信"}],"nameIdentifiers":[{"nameIdentifier":"1705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安達, 孝浩"}],"nameIdentifiers":[{"nameIdentifier":"1706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河口, 和寛"}],"nameIdentifiers":[{"nameIdentifier":"1707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩倉, 啓子"}],"nameIdentifiers":[{"nameIdentifier":"1708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鷲見, 信好"}],"nameIdentifiers":[{"nameIdentifier":"1709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若林, 克己"}],"nameIdentifiers":[{"nameIdentifier":"1710","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-18"}],"displaytype":"detail","filename":"JTS22_187.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JTS22_187.pdf","url":"https://gunma-u.repo.nii.ac.jp/record/1304/files/JTS22_187.pdf"},"version_id":"d60a0d19-d7c3-4b3a-9da1-2cacfe732fd4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規頻尿・尿失禁治療剤 (±)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydtoxy-2-phenylacetate monohydrochloride monohydrate (NS-21) のラットにおける甲状腺機能充進の機序","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規頻尿・尿失禁治療剤 (±)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydtoxy-2-phenylacetate monohydrochloride monohydrate (NS-21) のラットにおける甲状腺機能充進の機序"},{"subitem_title":"THE MECHANISM OF INCREASED THYROIDAL FUNCTION CAUSED BY (±)-4-DIETHYLAMINO-1,1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRIDTE(NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, ADMINISTRATION IN RATS","subitem_title_language":"en"}]},"item_type_id":"6","owner":"2","path":["381"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-31"},"publish_date":"2008-03-31","publish_status":"0","recid":"1304","relation_version_is_last":true,"title":["新規頻尿・尿失禁治療剤 (±)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydtoxy-2-phenylacetate monohydrochloride monohydrate (NS-21) のラットにおける甲状腺機能充進の機序"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-06-19T13:49:12.731439+00:00"}