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Purine metabolic enzymes in lymphocytes. III. Effects of immunosuppressants on adenosine deaminase and purine nucleoside phosphorylase activities
http://hdl.handle.net/10087/1815
http://hdl.handle.net/10087/1815af799de3-6552-414b-a31e-21fa2d2f8a0e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004436692.pdf (456.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-12-17 | |||||
| タイトル | ||||||
| タイトル | Purine metabolic enzymes in lymphocytes. III. Effects of immunosuppressants on adenosine deaminase and purine nucleoside phosphorylase activities | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 著者 |
Kurashige, Satonori
× Kurashige, Satonori× Akuzawa, Yuki× Yoshida, Toshiharu× Kodama, Kazue |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mice were treated with a single injection of 6-mercaptopurine riboside (6MP-R), predonine or cyclophosphamide (CY), and the effects of these immunosuppressants on blastogenic responses to phytohemagglutinin P (PHA-P) or bacterial lipopoly saccharide (LPS) and on adenosine deaminase (ADA) or purine nucleoside phosphorylase (PNP) activities were studied with spleen lymphocytes. The retardation of blastogenic responses to both PHA-P and LPS were associated with the retardation of both intracellular ADA and PNP activities in 6MP-R-treated mouse spleen lymphocytes. Both PHA and LPS responses were suppressed in lymphocytes from mice treated with predonine, whereas no suppression of both ADA and PNP activities was observed. In mice treated with CY, LPS response of spleen lymphocytes was markedly suppressed but PHA response was almost the same with that of normal lymphocytes. PNP activity was retarded in lymphocytes of CY-treated mice, while ADA activity of them was rather enahnced. These results suggest that the suppression with 6MP-R may be corresponding to the inherited immunodeficiency with enzyme deficiency, and that the suppression with predonine may be corresponding to immunodeficiency which is not associated with enzyme deficiency. | |||||
| 書誌情報 |
群馬大学医療技術短期大学部紀要 巻 3, p. 93-103, 発行日 1983-03-30 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0389-7540 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11389413 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版者 | ||||||
| 出版者 | 群馬大学医療技術短期大学部 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Departmental Bulletin Paper | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
