| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2007-12-20 |
| タイトル |
|
|
タイトル |
Antineoplastic Effects of Interferon-Alpha and -Gamma in Metastatic Renal Cell Carcinoma Xenografts in Nude Mice |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Interferon-alpha |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Interferon-gamma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Renal Cell Carcinoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Nude Mice |
| 著者 |
Ito, Yoshikazu Z.
Hiromachi, Sachiko
Shirahama, Akiko
Arai, Michiko
Futawatari, Tamae
Nakazato, Yoichi a6fda3e0d86bb4578a02926de06c4502
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Combination treatment with human natural interferon-alpha (IFN-alpha) and natural interferon-gamma (IFN-gamma) markedly reduced the weight of metastatic human renal cell carcinoma (RCC) transplanted into nude mice. Monotherapy with IFN-alpha or IFN-gamma inhibited the tumor growth without reducing the tumor weight. After combination treatment with IFN-alpha and-gamma, histological features showed notable reduction in the number of mitotic tumor cells and appreciable fibrosis in the stroma of the tumor. Infiltration of macrophages in the tumor was sparse. The results suggested that the antitumor activity of the IFNs is by direct cellular action. The general condition of tumor-bearing mice treated with IFN-alpha and-gamma was well retained, while marked emaciation was observed in the untreated tumor-bearing animals. The finding indicated that the combination treatment of RCC with IFN-alpha and-gamma may reduce the tumor burden of host mice. |
| 書誌情報 |
群馬大学医療技術短期大学部紀要
巻 14,
p. 149-157,
発行日 1994-03-31
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0389-7540 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00068340 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版者 |
|
|
出版者 |
群馬大学医療技術短期大学部 |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Departmental Bulletin Paper |
| 更新日 |
|
|
日付 |
2017-03-27 |
|
日付タイプ |
Created |
KJ00004436334.pdf (805.5 kB)
