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消化器癌患者リンパ球中のNK・LAK細胞手術による影響
http://hdl.handle.net/10087/2052
http://hdl.handle.net/10087/2052aa212d03-4371-4ca8-9ed8-a2ddfe54ed80
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004436369.pdf (451.9 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-20 | |||||
| タイトル | ||||||
| タイトル | 消化器癌患者リンパ球中のNK・LAK細胞手術による影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| その他のタイトル | ||||||
| その他のタイトル | Natural Killer Cells and Lymhpokine-Activated Killer Cells in Patients Suffered from Gastrointestinal Cancer : Effects of the Operation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NK cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | LAK cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cytotoxicity | |||||
| 著者 |
阿久沢, 由紀
× 阿久沢, 由紀× 倉茂, 達徳 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We studied in this paper on the effects of the operation on natural killer (NK) cells and lymphokine-activated killer (LAK) cells in the cancer patients. The cytotoxic activities of lymphocytes against both K562 cells and Daudi cells were significantly suppressed by the operation when those activities were determined at 2 weeks after operation and their activities recovered at 4 weeks after. However, lymphocytes collected at 2 weeks after operation and stimulated in vitro with IL2 showed the same activity against K562 cells as those of lymphocytes collected before operation but did not against Daudi cells. By the CD antigen analysis, in lymphocytes collected from the cancer patients, the number of CD16-positive-CD56-negative cells were not effected by the operation and significant increase was observed by the in vitro IL2 stimulation. By the contrast, CD16(+)-CD56(+) cells were markedly reduced in their number and were not increased by the in vitro IL2 stimulation, whereas the number of CD16(+)-CD56(+) cells increased after IL2 stimulation in the lymphocytes collected from normal human. These results suggest that the operation does not induce NK cell deficiency but dose LAK cell deficiency through the defect of differentiation of CD16(+)-CD56(-) NK cells to CD16(+)-CD56(+) LAK cells or of CD16(+)-56(+) progenitor cells to mature LAK cells. | |||||
| 書誌情報 |
群馬大学医療技術短期大学部紀要 巻 15, p. 85-90, 発行日 1995-03-31 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0389-7540 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00068340 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版者 | ||||||
| 出版者 | 群馬大学医療技術短期大学部 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Departmental Bulletin Paper | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
