| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2007-12-21 |
| タイトル |
|
|
タイトル |
LIMITED EFFECTS OF ANTIANDROGENS AND GONADOTROPIN-RELEASING HORMONE AGONIST ON TRANSPLANTABLE HUMAN PROSTATIC CANCER HONDA |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Antiandrogens |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Gonadotropin-Releasing Hormone Agonist |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Human Prostatic Cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Nude Mice |
| 著者 |
Ito, Yoshikazu Z.
Kuroiwa, Syunsuke
Hiromachi, Sachiko
Futawatari, Tamae
Arai, Michiko
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Human prostatic cancer transplanted into nude mice (HONDA) was treated with nonsteroidal antiandrogen, flutamide (FLT) or steroidal antiandrogen, chlormadinone acetate (CMA), with the doses of 50 mg and 200 mg for 28 days, and with a 5 μg daily dose of gonadotropin-releasing hormone agonist, leuprolide (LEU), for 8 weeks separately. Administration of 200 mg of FLT showed the most significant inhibition of the tumor growth followed in decreasing order by 200 mg of FLT, and 50 mg FLT. Monotherapy with 50 mg of CMA showed no effect on the growth of the tumor, suggesting that FLT is more potent antiandrogen than CMA. However, there was no reduction of the tumor weight despite the treatment with these agents. Orchiectomy markedly reduced the tumor weight. The weight of seminal vesicles and ventral prostate of the host mice were reduced significantly after the treatment with these antiandrogens, suggesting that there was substantial suppression of endogenous androgen action in these organs. Notable reduction of serum human prostatic acid phosphatase in the tumor-bearing mice was observed. Monotreatment with LEU did not inhibit the tumor growth, indicating the impairment of pituitary-gonadal axis of the nude mice. There was no changes in the content of the androgen receptor in the tumor cells regardless of the treatment. These results indicate that inhibitory effects of the antiandrogens in this experimental system is by direct cellular action. Although orchiectomy indicates the total androgen blockade in the mice, the discrepancy between the continuous tendency of the tumor growth notwithstanding antiandrogen treatment and the suppression of the endogenous androgen action suggests that growth-promoting factors other than androgens exist in the cancer family. |
| 書誌情報 |
群馬大学医療技術短期大学部紀要
巻 15,
p. 159-165,
発行日 1995-03-31
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0389-7540 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00068340 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版者 |
|
|
出版者 |
群馬大学医療技術短期大学部 |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Departmental Bulletin Paper |
| 更新日 |
|
|
日付 |
2017-03-27 |
|
日付タイプ |
Created |
KJ00004436380.pdf (365.0 kB)
