WEKO3
アイテム
Human Prostate Cancer Xenograft as a Tool for Screening of Efficacious Antiandrogens
http://hdl.handle.net/10087/2121
http://hdl.handle.net/10087/2121149895d4-6641-4f64-b2fd-e5a27829be01
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004436453.pdf (335.4 kB)
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-20 | |||||
| タイトル | ||||||
| タイトル | Human Prostate Cancer Xenograft as a Tool for Screening of Efficacious Antiandrogens | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Human prostate cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Antiandrogen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Prostate specific antigen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Prostatic acid phosphatase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nude mice | |||||
| 著者 |
Ito, Yoshikazu Z.
× Ito, Yoshikazu Z.× Hiromachi, Sachiko× Futawatari, Tamae× Arai, Michiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The efficacies of the steroidal antiandrogens chlormadinone acetate (CMA), 17 α-acetoxy-6-chloro-2-oxa-4, 6-pregnadiene-3, 20-dione (TZP), and cyproterone acetate (CypA) for retardation of the growth of androgen-dependent human prostatic adenocarcinoma transplanted into nude mice (Honda tumor) were tested. CypA inhibited the growth of these tumors, while CMA and TZP did not affect the weight of cancer tissue at the doses examined. Serum levels of human prostatic acid phosphatase (PAP) in the tumor-bearing mice were very sensitive to the administration of antiandrogens, but the levels were not dependent on the changes in tumor weight. In contrast, human prostate-specific antigen (PSA) levels in the blood of the host mice were correlated with the weight of the tumors, and were independent of treatment with antiandrogens. Castration of the cancer-bearing mice resulted in reductions in all experimental parameters tested. The validity of PSA-secreting androgen-dependent human prostate cancer xenograft as a tool for screening of efficacious antiandrogens will be discussed. | |||||
| 書誌情報 |
群馬大学医療技術短期大学部紀要 巻 17, p. 151-156, 発行日 1997-03-31 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0389-7540 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00068340 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版者 | ||||||
| 出版者 | 群馬大学医療技術短期大学部 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Departmental Bulletin Paper | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
