| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2010-05-17 |
| タイトル |
|
|
タイトル |
Neuronal expression of c-Fos protein in the brain after intraperitoneal injection of leptin in Wistar rats |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Brain |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Central nervous system |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
c-Fos |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Leptin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Neurons |
| 著者 |
TAKAYAMA, Kiyoshige
KAWATA, Haruka
TAKAHARA, Ryohta
TOMITA, Kazuhide
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Leptin has been recognized to be an important neuroendocrine signal in the\nregulation of food intake and energy balance. We aimed to survey central neurons that might be\nactivated after peripheral administration of leptin, by examining the distribution of neurons\nexpressing c-Fos protein. Leptin dissolved at a dose of 500 μg/kg in physiological saline was\nintraperitoneally injected in Wistar rats. One and a half hours after the injection, rats were\ntranscardially perfused with saline and fixed with fixatives. The brain was removed and\nsectioned at 40 μm in thickness. Every fourth section was treated with anti-c-Fos antiserum,\nand c-Fos protein was immunohistochemically stained using the avidin-biotin complex method.\nControl rats were injected with saline solution, and brain sections were processed similarly as\ndescribed above. It was found that leptin injected intraperitoneally induced the neuronal\nexpression of c-Fos protein in several nuclei throughout the brain. In the central nucleus\namygdala, ventromedial nucleus of hypothalamus, periaqueductal gray matter, lateral\nparabrachial nucleus, and the solitary tract nucleus, numbers of neurons expressing c-Fos\nprotein were much more in the test experiments than those in the control experiments.\nIntraperitoneally injected leptin was found to stimulate central neurons that may play some\nroles in the regulation of such as a food intake. |
| 書誌情報 |
群馬保健学紀要
巻 28,
p. 1-8,
発行日 2008-03
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1343-4179 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11260213 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版者 |
|
|
出版者 |
群馬大学医学部保健学科 |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Departmental Bulletin Paper |
| 更新日 |
|
|
日付 |
2017-03-27 |
|
日付タイプ |
Created |
HKJ28-001-008.pdf (187.5 kB)
