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Effects of peripheral administration of rat urotensinII on circulation, and on distribution of c-Fos immunoreactive neurons in the brain
http://hdl.handle.net/10087/5375
http://hdl.handle.net/10087/5375c81a9e80-7fd4-4a94-b717-39ebed3674c6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HKJ30-083-088.pdf (2.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2010-05-19 | |||||
| タイトル | ||||||
| タイトル | Effects of peripheral administration of rat urotensinII on circulation, and on distribution of c-Fos immunoreactive neurons in the brain | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rat urotensinII | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cardiovascular responses | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Brain | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Neuron | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | c-Fos | |||||
| 著者 |
TAKAYAMA, Kiyoshige
× TAKAYAMA, Kiyoshige× OBINATA, Shunsuke× INOUE, Midori× NAKATA, Ayuko× WAKAMATSU, Eriko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The purpose of this study was to examine the effects of intravenous injection of\nurotensinII on the systemic blood pressure and heart rate, and to examine whether the\nintraperitoneal administration of urotensinII evoked the stimulation of central neurons.\nUrotensin, originally isolated fish neuro-endocrine systems, is a peptide which consists of 12\namino acids. Lately human urotensinII was identified to be consisted from 11 amino acids.\nReceptors of urotensin have been found to highly distribute in the mammalian cadrdiovascular\nsystems. It has been reported that urotensin evoked contraction of thoracic artery, while the\ndilatation of blood vessels was alternatively induced. In this study, we examined the effects of\nperipheral injection of rat urotensinII consisted of 14 amino acids on the circulation and on the\nactivity of neurons in the brain. It was found that intravenous injection of rat urotensinII\nelicited dose-dependently decrease in blood pressure, and increase or decrease in heart rate.\nTo examine whether an intraperitoneal injection of rat urotensinII induced an excitation of\ncentral neurons, we used immunohistochemical method to study the expression of c-Fos\nprotein in neurons of the rat brain after intraperitoneal injection of rat urotensinII (test\nexperiment). In the control experiment rat was intraperitoneally injected saline solution\nwithout rat urotensinII. It was found that intraperitoneal injection of rat urotensinII induced\nexpression of c-Fos protein in several nuclei in the brain. These results suggested that rat\nurotensinII might exhibit physiological functions via central neuronal pathway as well as\nperipheral direct pathways. | |||||
| 書誌情報 |
群馬保健学紀要 巻 30, p. 83-88, 発行日 2010-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1343-4179 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11260213 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版者 | ||||||
| 出版者 | 群馬大学医学部保健学科 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Departmental Bulletin Paper | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
