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pH-dependent Formation of Membranous Cytoplasmic Body-like Structure of Ganglioside GM1/Bis(Monoacylglycero)Phosphate Mixed Membranes
http://hdl.handle.net/10087/3148
http://hdl.handle.net/10087/31488c9ea4b7-aec0-4c07-82c8-6b7964de3278
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
manuscript_BJL_LBPAGM1.pdf (443.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-02 | |||||
| タイトル | ||||||
| タイトル | pH-dependent Formation of Membranous Cytoplasmic Body-like Structure of Ganglioside GM1/Bis(Monoacylglycero)Phosphate Mixed Membranes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lysobisphosphatidic acid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cholesterol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | freeze fracture electron microscopy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gangliosidosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | late endosome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | small-angle x-ray scattering | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hayakawa, Tomohiro
× Hayakawa, Tomohiro× Makino, Asami× Murate, Motohide× Sugimoto, Ichiro× Hashimoto, Yasuhiro× Takahashi, Hiroshi× Ito, Kazuki× Fujisawa, Tetsuro× Matsuo, Hirotami× Kobayashi, Toshihide |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Membrane structures of the mixtures of ganglioside GM1 and endosome specific lipid, bis(monoacylglycero)phosphate (BMP, also known as lysobisphosphatidic acid, LBPA) were examined at various pH conditions by freeze-fracture electron microscopy and small-angle x-ray scattering (SAXS). At pH 8.5 – 6.5, a GM1/BMP (1/1 mol/mol) mixture formed small vesicular aggregates, whereas the mixture formed closely packed lamellar structures under acidic conditions (pH 5.5, 4.6) with the lamellar repeat distance of 8.06 nm. Since BMP alone exhibits a diffuse lamellar structure at a broad range of pH values and GM1 forms a micelle, the present results indicate that both GM1 and BMP are required to produce the closely stacked multilamellar vesicles. These vesicles resemble membranous cytoplasmic bodies (MCB) in cells derived from patients suffering from GM1 gangliosidosis. Similar to GM1 gangliosidosis, cholesterol was trapped in BMP vesicles in GM1- and in a low pH-dependent manner. Studies employing different gangliosides and a GM1 analog suggest the importance of sugar chains and a sialic acid of GM1 in the pH-dependent structural change of GM1/BMP membranes. | |||||
| 書誌情報 |
Biophysical journal 巻 92, p. L13-L16, 発行日 2007 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-3495 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00566095 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/info:doi/10.1529/biophysj.106.098657 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | Biophysical Society | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 関係URI | ||||||
| 関連名称 | http://www.biophysj.org/ | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
