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Identification of nesfatin-1 as a satiety molecule in the hypothalamus
http://hdl.handle.net/10087/1254
http://hdl.handle.net/10087/1254134c7d3b-8284-4c68-9402-a837023c0b2c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Nature443_709.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2007-03-29 | |||||
| タイトル | ||||||
| タイトル | Identification of nesfatin-1 as a satiety molecule in the hypothalamus | |||||
| タイトル | ||||||
| タイトル | 生理：視床下部に局在する食欲抑制分子であるネスファチン-1の発見 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| その他のタイトル | ||||||
| その他のタイトル | 生理：視床下部に局在する食欲抑制分子であるネスファチン-1の発見 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Oh-I, Shinsuke
× Oh-I, Shinsuke× Shimizu, Hiroyuki× Satoh, Tetsurou× Okada, Shuichi× Adachi, Sachika× Inoue, Kinji× Eguchi, Hiroshi× Yamamoto, Masanori× Imaki, Toshihiro× Hashimoto, Koushi× Tsuchiya, Takafumi× Monden, Tsuyoshi× Horiguchi, Kazuhiko× Yamada, Masanobu× Mori, Masatomo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The brain hypothalamus contains certain secreted molecules that are important in regulating feeding behaviour. Here we show that nesfatin, corresponding to NEFA/nucleobindin2 (NUCB2), a secreted protein of unknown function, is expressed in the appetite-control hypothalamic nuclei in rats. Intracerebroventricular (i.c.v.) injection of NUCB2 reduces feeding. Rat cerebrospinal fluid contains nesfatin-1, an amino-terminal fragment derived from NUCB2, and its expression is decreased in the hypothalamic paraventricular nucleus under starved conditions. I.c.v. injection of nesfatin-1 decreases food intake in a dose-dependent manner, whereas injection of an antibody neutralizing nesfatin-1 stimulates appetite. In contrast, i.c.v. injection of other possible fragments processed from NUCB2 does not promote satiety, and conversion of NUCB2 to nesfatin-1 is necessary to induce feeding suppression. Chronic i.c.v. injection of nesfatin-1 reduces body weight, whereas rats gain body weight after chronic i.c.v. injection of antisense morpholino oligonucleotide against the gene encoding NUCB2. Nesfatin-1-induced anorexia occurs in Zucker rats with a leptin receptor mutation, and an anti-nesfatin-1 antibody does not block leptin-induced anorexia. In contrast, central injection of alpha-melanocyte-stimulating hormone elevates NUCB2 gene expression in the paraventricular nucleus, and satiety by nesfatin-1 is abolished by an antagonist of the melanocortin-3/4 receptor. We identify nesfatin-1 as a satiety molecule that is associated with melanocortin signalling in the hypothalamus. | |||||
| 書誌情報 |
Nature 号 443, p. 709-712, 発行日 2006-10-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0028-0836 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00752384 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 17036007 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1038/nature05162 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 関係URI | ||||||
| 関連名称 | http://www.nature.com/npg/ | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
