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アイテム
動脈硬化と酸化ストレス(<特集>動脈硬化とアフェレシス)
http://hdl.handle.net/10087/5579
http://hdl.handle.net/10087/5579f870b469-b016-438c-a4f0-e29ac830eba0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
110006614000.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-07-23 | |||||
| タイトル | ||||||
| タイトル | 動脈硬化と酸化ストレス(<特集>動脈硬化とアフェレシス) | |||||
| タイトル | ||||||
| タイトル | Atherosclerosis and Oxidative Stress | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| その他のタイトル | ||||||
| その他のタイトル | Atherosclerosis and Oxidative Stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oxidative stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | reactive oxygen species | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NAD (P) H oxidase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | antioxidant therapy | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
倉林, 正彦
× 倉林, 正彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the presence of reactive oxygen species (ROS) such as hydrogen peroxide (H_2O_2) and the superoxide anion (O_2^-), low-density lipoprotein (LDL) cholesterol can become oxidized to form a highly atherogenic lipoprotein species. In an in vivo study, ROS production was demonstrated in human atherosclerotic plaques and human coronary resistant arteries. Moreover, the role of ROS in the proatherogenic actions of angiotensin II (Ang II) has been well documented in a number of experimental studies. In VSMC in vitro, subnanomolar concentrations of Ang II induces NAD (P) H oxidase activity, in which the ROS produced serve as intracellular secondary messengers, mediating the mitogenic response. Thus, induction of vascular ROS tone is probably a major mechanism by which Ang II enhances atherosclerosis. Antioxidant therapy is supposed to be effective in the early stage of atherosclerosis by preventing LDL oxidation and oxidative lesion of the endothelium. Bioactive components of food which are of special interest, including vitamin E, vitamin C, and β-carotene, are characterized by antioxidant properties. There have been several prospective, placebo-control, randomized clinical trials to evaluate the efficacy of these compounds. However, results are not consistent and thus further studies are necessary. | |||||
| 書誌情報 |
日本アフェレシス学会雑誌 巻 27, 号 1, p. 22-26, 発行日 2008-02-29 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13405888 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11604174 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 日本アフェレシス学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
