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アイテム
Expression Profile of 1,000 mRNAs from Rat Retina
http://hdl.handle.net/10087/4363
http://hdl.handle.net/10087/4363489eef4b-b3aa-4141-945b-f4e0f71ec0c6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
55_5.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-01-06 | |||||
| タイトル | ||||||
| タイトル | Expression Profile of 1,000 mRNAs from Rat Retina | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | expressed sequence tag (EST) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | vascular endothelial growth factor (VEGF) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | islet | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | type 2 diabetes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | diabetic retinopathy | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamada, Norihiro
× Yamada, Norihiro× Shihara, Nobuyuki× Horikawa, Yukio× Wang, Hong× Takeda, Jun× Kishi, Shoji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Backgrounds & Aims : Diabetic retinopathy is a major cause of new-onset blindness among diabetic adults that is characterized by increased vascular permeability, tissue ischemia, and neovascularization. To clarify the molecular mechanism responsible in the pathogenesis, it is important to understand the entire transcriptome of the retina tissue of multiple organisms. Methods : Since the genes responsible for the development of diabetic retinopathy might also be expressed in pancreatic β cells and play a crucial role in the regulation of insulin secretion, we compared the sequences with those identified in rat pancreatic islets after removal of house-keeping genes. Results : In the present study, we isolated and analyzed 1,000 cDNA sequences from rat retina as expressed sequence tags (ESTs). Nucleotide and peptide database searches found that 390 of the sequences represented known rat genes and an additional 266 sequences corresponded to ESTs identified in other tissues or cells. 141 of the sequences were not related to any of the sequences deposited in the databases. Conclusions : 123 commonly expressed genes were identified in the two tissues, all of which should be useful in studies of the development diabetes mellitus and retinal complications and possible therapeutic targets. | |||||
| 書誌情報 |
The Kitakanto medical journal = 北関東医学 巻 55, 号 1, p. 5-12, 発行日 2005-02-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1343-2826 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10585677 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 北関東医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
