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Serum Thrombomodulin in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (MPO-ANCA)-Associated Vasculitis.
http://hdl.handle.net/10087/4368
http://hdl.handle.net/10087/43684af4a8a6-c3cb-41c2-8ef3-0aea1cc622ff
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
55_13.pdf (763.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-01-06 | |||||
| タイトル | ||||||
| タイトル | Serum Thrombomodulin in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (MPO-ANCA)-Associated Vasculitis. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | thrombomodulin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MPO-ANCA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | vasculitis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hayashi, Junichi
× Hayashi, Junichi× Hiromura, Keiju× Kitahara, Tokuyuki× Kaneko, Yoriaki× Kuroiwa, Takashi× Ueki, Kazue× Nojima, Yoshihisa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and Aims : Although serum or plasma thrombomodulin (TM) was reported to be increased in various diseases with vascular injuries, blood TM was also shown to be influenced by renal function. In this study, we determined whether serum TM (sTM) could be a marker of vascular injury in patients with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis, in which kidneys are often affected. Methods : Thirteen patients with MPO-ANCA-associated vasculitis were investigated and 43 patients with chronic glomerulonephritis (CGN) served as a control. sTM was measured by one-step sandwich enzyme immunoassay method. Results : A significant positive correlation was found between sTM and serum creatinine (sCr) (sTM=2.24×sCr+2.16, r=0.91, P<0.001) in patients with CGN. In order to correct sTM for renal function, we calculated corrected sTM according to the following formula : corrected sTM (%)=[measured sTM/expected sTM at the measured sCr]×100=[sTM/(2.24×sCr+2.16)]×100. Patients with MPO-ANCA-associated vasculitis tended to have lower levels of corrected sTM before treatment compared to patients with CGN, but not significantly (86.8±23.2% vs. 98.7±18.3%, ANCA vs. CGN, P=0.12). Corrected sTM was increased significantly within 1 month after the beginning of treatment (145.7±46.9%, P=0.008, vs. before treatment in each patient). In remission, corrected sTM returned to the same levels of CGN (104.5±38.6%, P=0.03, vs. within 1 month in each patient). Conclusions : These results showed that sTM corrected for renal function does not simply reflect disease activity in MPO-ANCA-associated vasculitis. | |||||
| 書誌情報 |
The Kitakanto medical journal = 北関東医学 巻 55, 号 1, p. 13-18, 発行日 2005-02-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1343-2826 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10585677 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 北関東医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
