WEKO3
アイテム
Regulation of Proliferation and Steroidogenesis in Human Granulosa Cells
http://hdl.handle.net/10087/1479
http://hdl.handle.net/10087/1479927e9c51-c11e-4429-bd1b-61a75be1d111
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
57_157.pdf (326.8 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-10-05 | |||||
| タイトル | ||||||
| タイトル | Regulation of Proliferation and Steroidogenesis in Human Granulosa Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GDF-9 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cAMP | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | SVOG cells and HOXA7 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Asahina, Haruka
× Asahina, Haruka |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and Aims : Human follicles selected for further development are thought to receive precise\nsignals from gonadotropins and locally produced growth factors for survival. In this experiment, the\nmechanisms of the regulation of proliferation and steroidogenesis by GDF-9 and Br-cAMP in human\novarian cells were investigated. Methods : SVOG cells were cultured and treated with GDF-9 and\nBr-cAMP. The expression of HOXA7 and cofactors were examined by Western blot analysis and/or\nRT-PCR. The cell proliferation was measured by thymidine incorporation assay. Results : Treatment\nwith GDF-9 resulted in a significant increase of cell proliferation. Although the treatment with\nBr-cAMP increased the expression of StAR protein, this treatment resulted in a significant decrease of cell\nproliferation compared with the control and no change in HOXA7 or its cofactors. Conclusion : The\npresent study demonstrated that GDF-9 had a stimulatory effect and cAMP had an inhibitory effect on\nthe proliferation of SVOG cells. These results may reflect the characteristics of this human cell line as\nluteinized granulosa cell. Therefore, this culture system will be useful for studying the effects of local\nfactors and gonadotropin on the regulation of human luteinized granulosa cells in the future. | |||||
| 書誌情報 |
The Kitakanto medical journal = 北関東医学 巻 57, 号 2, p. 157-164, 発行日 2007-05-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1343-2826 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10585677 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 北関東医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
