{"created":"2023-06-19T08:38:59.244001+00:00","id":5945,"links":{},"metadata":{"_buckets":{"deposit":"d4b0305a-eb3d-421d-bccf-0473c31c69fc"},"_deposit":{"created_by":2,"id":"5945","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5945"},"status":"published"},"_oai":{"id":"oai:gunma-u.repo.nii.ac.jp:00005945","sets":["719:760:761:770"]},"author_link":["18173"],"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"164","bibliographicPageStart":"157","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"The Kitakanto medical journal = 北関東医学"}]}]},"item_6_date_61":{"attribute_name":"更新日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-03-27","subitem_date_issued_type":"Created"}]},"item_6_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_6_description_39":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and Aims : Human follicles selected for further development are thought to receive precise\\nsignals from gonadotropins and locally produced growth factors for survival. In this experiment, the\\nmechanisms of the regulation of proliferation and steroidogenesis by GDF-9 and Br-cAMP in human\\novarian cells were investigated. Methods : SVOG cells were cultured and treated with GDF-9 and\\nBr-cAMP. The expression of HOXA7 and cofactors were examined by Western blot analysis and/or\\nRT-PCR. The cell proliferation was measured by thymidine incorporation assay. Results : Treatment\\nwith GDF-9 resulted in a significant increase of cell proliferation. Although the treatment with\\nBr-cAMP increased the expression of StAR protein, this treatment resulted in a significant decrease of cell\\nproliferation compared with the control and no change in HOXA7 or its cofactors. Conclusion : The\\npresent study demonstrated that GDF-9 had a stimulatory effect and cAMP had an inhibitory effect on\\nthe proliferation of SVOG cells. These results may reflect the characteristics of this human cell line as\\nluteinized granulosa cell. Therefore, this culture system will be useful for studying the effects of local\\nfactors and gonadotropin on the regulation of human luteinized granulosa cells in the future.","subitem_description_type":"Abstract"}]},"item_6_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"北関東医学会"}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1343-2826","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10585677","subitem_source_identifier_type":"NCID"}]},"item_6_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asahina, Haruka"}],"nameIdentifiers":[{"nameIdentifier":"18173","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-25"}],"displaytype":"detail","filename":"57_157.pdf","filesize":[{"value":"326.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"57_157.pdf","url":"https://gunma-u.repo.nii.ac.jp/record/5945/files/57_157.pdf"},"version_id":"02855bfb-7a79-441a-b720-a6c09bc69f17"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GDF-9","subitem_subject_scheme":"Other"},{"subitem_subject":"cAMP","subitem_subject_scheme":"Other"},{"subitem_subject":"SVOG cells and HOXA7","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of Proliferation and Steroidogenesis in Human Granulosa Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of Proliferation and Steroidogenesis in Human Granulosa Cells"}]},"item_type_id":"6","owner":"2","path":["770"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-10-05"},"publish_date":"2007-10-05","publish_status":"0","recid":"5945","relation_version_is_last":true,"title":["Regulation of Proliferation and Steroidogenesis in Human Granulosa Cells"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-06-19T11:39:08.648881+00:00"}