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Impaired Proliferation and Th1 Differentiation of CD4+ T Cells of SHPS-1 Mutant Mice
http://hdl.handle.net/10087/3476
http://hdl.handle.net/10087/3476a061592f-b12b-4c2e-895b-b94f45e09dec
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
58_133.pdf (266.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-10-21 | |||||
| タイトル | ||||||
| タイトル | Impaired Proliferation and Th1 Differentiation of CD4+ T Cells of SHPS-1 Mutant Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Th1/Th2 cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | autoimmunity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cell surface molecules | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | transgenic/knockout mice | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kaneko, Yuka
× Kaneko, Yuka× Kaneko, Yoriaki× Ohnishi, Hiroshi× Tomizawa, Takeshi× Okajo, Jun× Saito, Yasuyuki× Okuzawa, Chie× Murata, Yoji× Okazawa, Hideki× Nojima, Yoshihisa× Okamoto, Koichi× Matozaki, Takashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background & Aims: SHPS-1 is a transmembrane protein that binds the protein tyrosine phosphatases \nSHP-1 and SHP-2 through its cytoplasmic region. It is highly expressed on the surface of CD11c+\ndendritic cells (DCs) and macrophages. We have recently shown that priming of CD4+T cells by DCs \nis markedly impaired in mice that express a mutant form of SHPS-1 lacking most of the cytoplasmic \nregion. We have now evaluated further the functions of CD4+T cells derived from SHPS-1 mutant mice. \nMethods: The expression of cell surface molecules on CD4+T cells was examined by flow cytometry. \nThe proliferation of CD4+T cells was measured by［3H］thymidine incorporation. Cytokine production \nby CD4+T cells was measured by ELISA. Results: SHPS-1 is expressed at low level on CD4+T \ncells of wild-type mice. The T cell receptor (TCR)-stimulated proliferation of CD4+T cells from \nSHPS-1 mutant mice was markedly decreased, whereas the TCR-stimulated production of IL-2 and \nIFN-γ by these cells was markedly increased, compared with those apparent with wild-type cells. \nDifferentiation of CD4+T cells from SHPS-1 mutant mice into Th1 cells was also impaired. Conclusions: Present results suggest that SHPS-1 is essential for proper regulation of CD4+T cell functions. | |||||
| 書誌情報 |
The Kitakanto medical journal = 北関東医学 巻 58, 号 2, p. 133-139, 発行日 2008-05-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1343-2826 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10585677 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 北関東医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
