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F-18-FDG Positron Emission Tomography Findings Correlate Pathological Proliferative Activity of Oral Squamous Cell Carcinoma
http://hdl.handle.net/10087/5456
http://hdl.handle.net/10087/5456e06b1086-9647-483b-998b-c2ecc945b570
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KMJ60_1.pdf (191.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-05-31 | |||||
| タイトル | ||||||
| タイトル | F-18-FDG Positron Emission Tomography Findings Correlate Pathological Proliferative Activity of Oral Squamous Cell Carcinoma | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Oral squamous cell carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | FDG PET | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cellular proliferation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p53 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Topoisomerase Iiα | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p63 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Osamu, Toyoizumi
× Osamu, Toyoizumi× Noboru, Oriuchi× Mitsuyuki, Miyakubo× Tomohiro, Ishikita× Yoshiki, Nakasone× Akihide, Negishi× Keigo, Endo× Takashi, Nakajima× Kenji, Mogi× Satoshi, Yokoo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background : It is still controversial whether FDG uptake is correlated with cellular proliferation and prognosis of oral squamous cell carcinoma (OSC). In this study, we performed PET study and immunohistochemical analysis to elucidate the relationship between FDG uptake and expression of cellular proliferative markers and pathological prognostic markers in patients with OSC. Methods : FDG PET and immunohistochemical staining have been carried out in sixteen patients with OSC. Tumor uptake of FDG was expressed with standardized uptake value (SUV). The expression of Ki-67, Topoisomerase IIα (Topo IIα), p53, and p63 in cancer cells was quantitatively assessed with positivity of the immunohistochemical staining. SUV was compared with the results of immunohistochemical analysis. Results : FDG PET study revealed that SUV ranged from 3.6 to 22.1 with average of 10.4. Average positive rate of Ki-67, Topo IIα, p53, and p63 was 68.9%, 58.9%, 72.0%, and 65.2%, respectively. Pearson product-moment correlation coefficient analysis revealed that SUV was significantly correlated with Ki-67 (r=0.616, p=0.01), Topo IIα (r=0.677, p=0.004), p53 (r=0.613, p=0.01), and p63 (r=0.710, p=0.002), respectively. Conclusion : The present preliminary study indicated that FDG uptake was closely correlated with pathological cellular proliferative and prognostic markers in patients with OSC. | |||||
| 書誌情報 |
The Kitakanto medical journal = 北関東医学 巻 60, 号 1, p. 1-8, 発行日 2010-02-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1343-2826 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10585677 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 北関東医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
