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Nelarabine resistance of childhood T-cell lymphoblastic leukemia/lymphoma cells
http://hdl.handle.net/10087/6015
http://hdl.handle.net/10087/6015b9906864-86cc-48eb-a5fe-fbd469e76804
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
61_119.pdf (197.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-07-26 | |||||
| タイトル | ||||||
| タイトル | Nelarabine resistance of childhood T-cell lymphoblastic leukemia/lymphoma cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nelarabine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytarabine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | T-ALL | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | T-LBL | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ENT-1 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kanazawa, Takashi
× Kanazawa, Takashi× Shiba, Norio× Aizawa, Akira× Okuno, Haruna× Tamura, Kazushi× Tsukada, Shota× Kumamoto, Tadashi× Yamada, Shiro× Kobayashi, Ysuko× Arakawa, Hirokazu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Nelarabine (NEL) is a new purine nucleoside analogue that has recently become available for both adults and children with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL)and T-lymphoblastic lymphoma (T-LBL). We studied the drug resistance profile of eight children with T-ALL/LBL using an in vitro cytotoxic assay including NEL. Furthermore, we tried to establish a NEL resistant T-ALL cell line model to investigate the mechanism of NEL resistance.\nResults : Four of 8 patients showed a higher 50% lethal concentration (LC,o) than the maximum clinical concentration of NEL. There were no correlations in LC,o values between NEL and other drugs. To study the mechanism of NEL resistance, we originally established a nucleoside an alogue resistant T-ALL Jurkat cell line model (Jurkat+C) induced by incubation in medium containing cytarabine (AraC) at LC,o ofthe control. Jurkat+C showed resistance to NEL and Fludarabine as well as AraC but not Daunorubicin. Next, we studied the role of Equivalent Nucleoside Transporter-1 (ENT-1), a major cellular nucleoside transporter, in the acquired drug resistance in Jurkat+ C. Nitrobenzylmercaptopurine riboside, an ENT-1-specific inhibitor, showed an inhibitory efTect of nucleoside analogues on in vitro toxicity in both Jurkat and Jurkat+C, while no difTerences in ENT-1 mRNA expression levels between Jurk at and Jurkat + C were found.\nConclusions: in vitro NEL resistance was seen in half of the tested childhood T-ALL cells. We could\nestablish the NEL resistant T-ALL cell line model by AraC exposure. ENT-1 may partly act as a\ntransporter of NEL, but not play a key role in AraC induced NEL resistance. This cell line model may\nbe usefu1 to provide a mechanism to explain NEL resistance. | |||||
| 書誌情報 |
The Kitakanto medical journal = 北関東医学 巻 61, 号 2, p. 119-126, 発行日 2011-05-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1343-2826 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10585677 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 北関東医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
