@article{oai:gunma-u.repo.nii.ac.jp:00007556, author = {Miyazawa, Yuri and Irisawa, Hiroyuki and Matsushima, Takafumi and Mitsui, Takeki and Uchiumi, Hideki and Saitoh, Takayuki and Handa, Hiroshi and Karasawa, Masamitsu and Murakami, Hirokazu and Tsukamoto, Norifumi and Nojima, Yoshihisa}, issue = {3}, journal = {The Kitakanto medical journal = 北関東医学}, month = {Aug}, note = {Journal Article, We describe a patient with biphenotypic acute leukemia (BAL) with T-lymphoid lineage and\nmyeloid lineage differentiation[BAL (T/M)]. Cytogenetic analysis revealed complex chromosomal\nabnormalities, including der(2)t(2;11)(p21;q23). Neither leukemia cells nor T-cell receptor gene\nrearrangements were detected in the bone marrow samples after four courses of high dose cytosine\narabinoside regimen. However, der(2)t(2;11)(p21;q23) anomaly persisted in most of metaphases.\nFluorescence in situ hybridization (FISH)analysis with a probe for MLL did not detect the split signal.\nForty-five cases of hematological disorder with t(2;11)(p21;q23) abnormality have been previously\nreported. The majority of such cases have been classified as myelodysplastic syndrome(MDS) or acute\nmyeloid leukemia (AML). This is the first case BAL (T/M) associated with a t(2;11)(p21;q23)\nanomaly.}, pages = {287--290}, title = {Der(2)t(2;11)(p21;q23), a Variant form of t(2;11), in Biphenotypic Acute Leukemia with T Lymphoid Lineage and M yeloid Lineage Differentiation}, volume = {62}, year = {2012} }