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Structure and thermal history dependant phase behavior of hydrated synthetic sphingomyelin analogue: 1,2-dimyristamido-1,2-deoxyphosphatidylcholine
http://hdl.handle.net/10087/3157
http://hdl.handle.net/10087/3157330cf98b-9a12-4c3a-89fb-bc7b6bc53499
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DDPC_final_ver.pdf (983.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-06 | |||||
| タイトル | ||||||
| タイトル | Structure and thermal history dependant phase behavior of hydrated synthetic sphingomyelin analogue: 1,2-dimyristamido-1,2-deoxyphosphatidylcholine | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | acylamino-phospholipid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | phase behavior | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | metastability | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hydrogen bond | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | differential scanning calorimetry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | X-ray diffraction | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Takahashi, Hiroshi
× Takahashi, Hiroshi× Okumura, Yukihisa× Sunamoto, Junzo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The physical properties of hydrated multilamellar sample of 1,2-dimyristamido-1,2-deoxyphosphatidylcholine (DDPC) were investigated by means of differential scanning calorimetry (DSC), static X-ray diffraction, and simultaneous DSC and X-ray diffraction. The DDPC is a synthetic sphingomyelin analogue and has two amide bonds in its hydrophobic parts. This paper reports on metastable phase behavior of the hydrated DDPC sample. By cooling from a chain-melted state at the rates of greater than 4 oC min-1, hydrated DDPC bilayers form a metastable gel phase. In the gel phase, the hydrophobic chains are tilted with respect to the bilayer normal, as like the gel phase of glycero-phosphatidylcholines. By heating, the metastable gel phase is transformed in to a stable phase associated with an exothermic heat event at 18.3 oC (DH = 14.6 kJ mol-1) and then the stable phase is transformed into a liquid-crystalline phase at 25.6 oC (DH = 42 kJ mol-1). The incubation at 17 oC for more than 1 hour also induces the formation of the stable phase. In the stable phase, the hydrophobic chains are packed into highly ordered crystal-like structure. However, the X-ray diffraction pattern of the stable phase suggested that the entire DDPC molecules do not form a two-dimensional molecular ordered lattice, differing from normal subgel phase of glycero-phosphatidylcholines. The structure and phase behavior of DDPC revealed by the present study are discussed from the viewpoint of hydrogen bonds. | |||||
| 書誌情報 |
Biochimica et biophysica acta. Biomembranes 巻 1713, p. 40-50, 発行日 2005-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0005-2736 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00564657 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 15950928 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/info:doi/10.1016/j.bbamem.2005.04.012 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 関係URI | ||||||
| 関連名称 | http://www.sciencedirect.com/science/journal/00052736 | |||||
| 関係URI | ||||||
| 関連名称 | http://www.sciencedirect.com/science/journal/00052736 | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
