WEKO3
アイテム
Does Hypoxic Preconditioning Induce Angiogenesis and Protect against Focal Cerebral Ischemic Damage in Rats?
http://hdl.handle.net/10087/5849
http://hdl.handle.net/10087/5849c9277dea-a03f-404c-aefe-189d9300d297
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
61_1.pdf (285.2 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-02-17 | |||||
| タイトル | ||||||
| タイトル | Does Hypoxic Preconditioning Induce Angiogenesis and Protect against Focal Cerebral Ischemic Damage in Rats? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hypoxia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | preconditioning | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tolerance | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endothelial cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | angiogenesis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kaie, Kagoshima
× Kaie, Kagoshima× Hideaki, Imai× Chisato, Kubota× Sandra, Puentes× Masashi, Kurachi× Yasuki, Ishizaki× Yuhei, Yoshimoto× Nobuhito, Saito |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and Aims: This study investigated whether hypoxic preconditioning(HP) induces ischemic tolerance in an established experimental model of permanent middle cerebral artery occlusion using rats. Methods: Animals were divided into the normoxia(control) and HP groups. HP was performed under normobaric conditions (7% O2 for 2 hours), 14 days before focal cerebral ischemia induction. the infarct volume was evaluated by quantitative histopathology. Immunofluorescence analysis was assessed at 24 hours after HP to examine the effect on proliferating cell and microglia /macrophage activation. Brain microvessel density was assessed 14 days after HP. Furthermore, the expression was evaluated of angiogenesis-related proteins such as hypoxia-inducible factor-1α and vascular endothelial growth factor proteins. Results: Hemisphere infarct volume in the HP group was significantly smaller than in the control group. Vascular endothelial growth factor and proliferating cell nuclear antigen expression was not increased after HP. HP tended to increase vessel density relative to the control group, but this did not achieve statistical significance. Conclusion: HP attenuated the infarct volume in rats. The phenomenon of ischemic tolerance may link HP with vascular remodeling. | |||||
| 書誌情報 |
The Kitakanto medical journal = 北関東医学 巻 61, 号 1, p. 1-8, 発行日 2011-02-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1343-2826 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10585677 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 北関東医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
