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Stress-induced Biomarkers in Liver with Non-alcohol Fatty Liver Diseases and Non-alcohol Steatohepatitis
http://hdl.handle.net/10087/8128
http://hdl.handle.net/10087/81283270077f-ed34-4639-8784-5643244417d1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
64_13.pdf (535.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-02-27 | |||||
| タイトル | ||||||
| タイトル | Stress-induced Biomarkers in Liver with Non-alcohol Fatty Liver Diseases and Non-alcohol Steatohepatitis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | adiponectin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | heme oxygenase -1 (HO-1) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | metallothionein (MT) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NAFLD (non-alcohol fatty liver) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NASH (non-alcoholic steatohepatitis) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ono, Hiromi
× Ono, Hiromi× Tanaka, Akira× Nakazato, Kyoumi× Hasegawa, Yutaka× Kim, Ke Ih× Kim, Soo Ryang× Nakajima, Katsuyuki× Nagamine, Takeaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background& Aims : A comparative study between plasma diagnostic markers and oxidative stressinduced biomarkers localized differently in the liver has not been reported in non-alcohol fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH). Methods : Pathological observations by Hematoxylin and Eosin (HE) staining and immunostaining by specific antibodies against metallothionein (MT)-1/2 and-3,heme oxygenase-1 (HO-1), adiponectin using biopsy samples and plasma diagnostic makers were determined in 37 cases. Results : The MT-1/2,HO-1 and adiponectin levels were all significantly reduced in the liver with NASH compared with NAFLD and control. MT-1/2 was most strongly stained in hepatocytes in the normal and NAFLD liver,while it was significantly reduced in NASH. Adiponectin was stained significantly less at blood vessels in NASH compared with NAFLD and controls. HO-1 was also stained significantly less in the Kupffer cells in NASH compared with NAFLD and controls. MT-3 was stained similarly among the three groups at blood vessel cells. Those biomarkers trended negatively with plasma liver injury biomarkers. Conclusions : The significantly reduced expression of oxidative stress-induced biomarkers in NASH may be associated with the degree of pathological damage. In particular, MT-1/2 appears to exert an important effect in hepatocytes against stress-induced damage in NASH. | |||||
| 書誌情報 |
The Kitakanto medical journal = 北関東医学 巻 64, 号 1, p. 13-22, 発行日 2014-02-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1343-2826 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN10585677 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 北関東医学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
| 更新日 | ||||||
| 日付 | 2017-03-27 | |||||
| 日付タイプ | Created | |||||
